When a trypanosome cell divides, all of the ~120 chromosomes has to equally partitioned into the two daughter cells. All 3 chromosomal classes are segregated through interactions with the mitotic spindle and all with great fidelity (an individual chromosome will be lost only once in more than 1000 cell divisions).
However, in trypanosomes the number of chromosomes far out-numbers the number of spindle microtubules and the molecular details of this segregation mechanism are almost entirely unknown. The lab is currently working to discover the components of the mitotic machinery in trypanosomes and what features of the small chromosomes enable them to interact with the spindle. This will reveal how an essential part of the trypanosome cell functions and will also tell us about the evolution of mitosis in other organisms.